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KMID : 0384620080190020095
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Korean Journal of Medical Physics
2008 Volume.19 No. 2 p.95 ~ p.101
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Evaluation of Antidepressant Drug Effect in a Depressive Animal Model by Proton MR Spectroscopy
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Kim Sang-Young
Hong Kwan-Soo
Choe Bo-Young
Woo Dong-Cheol
Choi Che-Bong
Kim Hwi-Yool
Yoon Seong-Ik
Lee Sung-Ho
Lee Hyun-Sung
Chong Chae-Joon
Jee Bo-Keun
Hong Sung-Tak
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Abstract
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In this study, we observed the alteration of choline signal intensity in hippocampus region of the depressive rat model induced by forced swimming test (FST). The purpose of this study was to evaluate the antidepressant efficacy in the depressive animal model using MR spectroscopy. Fourteen experimentally naive male Sprague-Dawley rats weighting were used as subjects. Drug injection group was exposed to the FST except for control group. The drugs were administered subcutaneously (SC) in a volume equivalent to 2ml/kg. And three injections were administered 23, 5, and 1h before beginning the given test. 1H MR spectra were obtained with use of a point resolved spectroscopy (PRESS) localization sequence performed according to the following parameters: repetition time, 2500 ms; echo time, 144 ms; 512 average; 2048 complex data points; voxel dimensions, ; acquisition time, 25min. There were no differences in NAA/Cr and Cho/Cr ratio between the right and the left hippocampus both normal control rats and antidepressant-injected rats. Also, no differences were observed in NAA/Cr and Cho/Cr ratio between the normal control rats and the antidepressant-injected rats both the right and the left hippocampus. In this study, we found the recovery of choline signals in the depressive animal model similar to normal control groups as injecting desipramine-HCl which was antidepressant causing anti-immobility effects. Thus, we demonstrated that MR spectroscopy was able to aid in evaluating the antidepressant effect of desipramine-HCl.
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KEYWORD
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Forced swimming test (FST), Desipramine-HCl, Magnetic resonance spectroscopy (MRS), Hippocampus
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